$1,780.00
The MazeEngineers Drosophila Matrix opens up unparalleled avenues for Drosophila experimentation. Drawing inspiration from the pioneering research of De Bivort et al, these matrices offer a suite of distinctive functionalities:
MazeEngineers offers custom-built behavioral mazes at no extra costādesigned to fit your exact research needs. Eliminate reproducibility issues from poor sizing or lingering scent cues with precision-engineered, modular, and smart mazes that adapt in real time to animal behavior. Publish new protocols, run adaptive experiments, and push the boundaries of behavioral science.
The Drosophila Locomotion Matrix is engineered to delve into the intricacies of locomotor behavior in Drosophila. This behavioral phenomenon encompasses a nuanced form of lateralization, where behaviors are preferentially performed on one side of the body or with a distinct chiral orientation (Buchanan, 2015). Unlike genetic dominance or morphological asymmetry, locomotor handedness is intricately linked to the asymmetric processing of sensory input by the subject. Within the Drosophila Locomotion Matrix, varied light and pattern configurations are harnessed to scrutinize the impact of specific sensory stimuli on Drosophila’s locomotion. The Y-maze Matrix configuration serves as an expedient tool for assessing chemosensory responses in Drosophila (Simonnet, 2014), while the T-maze Matrix configuration facilitates examinations of memory retention (Malik, 2014) and phototaxic reflexes in adult flies (Swinderen, 2011). Through meticulous analysis of Drosophila locomotor behavior across diverse maze array configurations, researchers can begin to unravel the complexities underlying the variability in physiological, morphological, and behavioral traits exhibited by Drosophila reared in homogeneous environments (Buchanan, 2015).
The Drosophila Labyrinth Array comprises four distinct layers, each serving a particular function. At the base lies the foundation, crafted from translucent material and adorned with a subtle luminescent backdrop. Rising from this foundation, the second layer manifests as the maze’s enclosures, customizable to suit experimental specifications. Regardless of the maze’s design, the walls stand uniformly at a height of 1/16th inch. Encompassing the maze is the third layer, an infrastructure engineered to fortify the array, ensuring its structural integrity. Finally, the fourth layer culminates the ensemble with a lid fashioned from non-reflective acrylic, completing the maze array’s configuration.
The maze can be modified to include both ā+ā and ā-ā configurations.
Number of flies loaded = 14 |
Number of flies in odor tube = 10 |
Number of flies in solvent tube = 4 |
Olfactory index formula: (number in the odor tube ā number in the solvent tube)//total number of loaded flies |
Olfactory index: (10-4)/14 = 0.429 |
Number of flies loaded = 13 |
Number of flies avoiding the shock paired odor (CSā) = 5 |
Number of flies choosing shock-paired odor (CS+) = 8 |
Performance index (PI) formula: (#CSā flies ā CS+ flies)/(# total flies) |
PI: (5-8)/13= -.231 |
Buchanan, Sean M. Kain, Jamey S., and de Bivort, Benjamin L. (2015).Ā Neuronal Control of Locomotor Handedness in Drosophila. PNAS, vol 112 (no. 21), p. 6700-6705.
Malik, Bilal R., and Hodge, James J.L. (2014).Ā Drosophila Adult Olfactory Shock Learning. Journal of Visualized Experiments, vol. 90 (e50107), p. 1-5.
Martin, Fernando, Charro, Maria J., and Alcarta, Esther. (2001).Ā Mutations Affecting the cAMP Transduction Pathway Modify Olfaction in Drosophila. J. Comp Physiol A, p. 359-370.
Simonnet, Megane M., Berthelot-Grosjean, Martine, Grosjean, Yael. (2014).Ā Testing Drosophila Olfaction with a Y-maze Assay. Journal of Visualized Experiments, vol. 88 (e51241), p. 1-4.
Swinderen, Bruno van. (2011).Ā Aversive Phototaxic Suppression Assay for Individual Adult Drosophila. Cold Spring Harbor Protocols, p. 1203-1205.
Alcorta E,Ā Rubio J. (1989).Ā Intrapopulational variation of olfactory responses in Drosophila melanogaster. Behav Genet ;19(2):285-99.
| Drosophila Maze Array | – (25 units), + (25 units), T (25 units), Y (25 units) |
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